HCID 14068933, compound → HCID 14068943, compound

HRID 1904788Notes

Reaction equation

HRID 1904788 reaction equation
[CH2:1]([N:8]1[C:13](=[O:14])[CH:12]2[C:10]([C:15]3[CH:20]=[CH:19][C:18]([N+:21]([O-])=O)=[CH:17][CH:16]=3)([CH2:11]2)[C:9]1=[O:24])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1>C(O)C.[Pd]>[NH2:21][C:18]1[CH:19]=[CH:20][C:15]([C:10]23[CH2:11][CH:12]2[C:13](=[O:14])[N:8]([CH2:1][C:2]2[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=2)[C:9]3=[O:24])=[CH:16][CH:17]=1

Participants

4

Reactant 1

HCID 14068933HCID 14068933, compound

Product 1

HCID 14068943HCID 14068943, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent2×

Procedure

Following the procedure of Example 3, a solution of 2.0 g of 3-benzyl-1-(4-nitrophenyl)-3-azabicyclo[3.1.0]hexane-2,4-dione in 100 ml of ethanol is hydrogenated in the presence of 0.2 g of 5% palladium on carbon and worked up, affording the title compound which melts at 154°-155° C. after recrystallsation from ethanol.

Sources & evidence

ORD record
ord-4189919050ab49e4b1942016fc4c41bc
Source dataset
uspto-grants-1989_06
Patent number
US04839379

Reaction notes

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