反应详情

In a glass bomb tube, 2.3 g of 1-(4-aminophenyl)-1,2-cyclopropanedicarboxylic acid are stirred in 80 ml of approx. 1N methanolic ammonia solution for 7 days at 100° C. The reaction mixture is evaporated to dryness and the residue is chromatographed over silica gel with hexane/ethyl acetate (4:6). Recrystallisation from ethanol affords white crystals of the title compound, which is identical with the title compound of Example 1.

1. customThe reaction mixture is evaporated to dryness
2. customthe residue is chromatographed over silica gel with hexane/ethyl acetate (4:6)
3. customRecrystallisation from ethanol