反应详情

An approx. 0.3 molar solution of diazomethane is added dropwise at 0° C. to a solution of 202 mg of 1-(4-aminophenyl)-3-azabicyclo[3.1.0]hexane-2,4-dione in 10 ml of methanol. The reaction mixture is allowed to stand for 16 hours, concentrated, and partitioned twice between ethyl acetate and water. The organic phases are dried over magnesium sulfate, filtered and concentrated. The residue is crystallised from ethyl acetate/petroleum ether, affording the title compound which is identical with the title compound of Example 3(a).

1. concentrationconcentrated
2. custompartitioned twice between ethyl acetate and water
3. dry with materialThe organic phases are dried over magnesium sulfate
4. filtrationfiltered
5. concentrationconcentrated
6. customThe residue is crystallised from ethyl acetate/petroleum ether