HCID 20038045, compound → HCID 20038049, compound

Participants

Reaction Steps

Following the procedure of Example 3, a solution of 6.0 g of 3-n-decyl-1-(4-nitrophenyl)-3-azabicyclo[3.1.0]hexane-2,4-dione in 120 ml of ethanol is hydrogenated in the presence of 0.3 g of 5% palladium on carbon and worked up, affording the title compound which melts at 92°-94° C. after recrystallisation from ethyl acetate. The starting material is synthesised in accordance with Example 3, starting from 4.6 g of 1-(4-nitrophenyl)-3-azabicyclo[3.1.0]hexane-2,4-dione, 0.72 g of sodium hydride (pract. Fluka) and 5.3 ml of 1-decyl bromide. The product is a yellow oil with Rf=0.50 on thin-layer silica gel plates in the system hexane/ethyl acetate (1:1).

Provenance & Evidence