Carbon Disulfide → HCID 14518047, compound

Participants

Reaction Steps

To a stirred and cooled (-10° C.) mixture of 20.8 parts of carbon disulfide, 9 parts of N,N'-methanetetraylbis[cyclohexanamine] and 135 parts of tetrahydrofuran was added dropwise a solution of 15 parts of 4-[[1-(phenylmethyl)-1H-benzimidazol-2-yl]methyl]-1-piperidineethanamine in tetrahydrofuran at a temperature below -10° C. The reaction mixture was allowed to reach room temperature and the solvent was evaporated. The residue was crystallized from acetonitrile. The precipitate was filtered off and the filtrate was evaporated, yielding 15 parts (89%) of 2-[[1-(2-isothiocyanatoethyl)4-piperidinyl]methyl]-1-(phenylmethyl)-1H-benzimidazole (395).

Provenance & Evidence