Acetone → HCID 53905017, compound

Participants

Reaction Steps

171.8 g of β-(2-benzofuryl)acrylic acid, synthesized in the manner as described in J. Chinese Chem. Soc. sev. II 8, pp. 374-379, and 101.5 g of triethylamine were added to 550 ml of acetone, to the mixture were added dropwise 75.9 g of chloroacetonitrile, and the mixture was refluxed by heating over a period of five hours. After the reaction, 400 ml of water were added to cool the reaction system, and the deposited crystals were filtered by a suction filter and then washed. The obtained crystals were recrystallized from acetone to thereby obtain 187 g of β-(2-benzofuryl)acrylic acid cyanomethyl ester having a melting point between 119° C. and 121° C.

Provenance & Evidence