Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Triphenylphosphine | HCID 11776 | — |
| Reactant | alpha-Methyl-4-(2-methylpropyl)benzeneacetyl chloride | HCID 595157 | — |
| Solvent | Acetone | HCID 180 | — |
| Product | Ibuprofenal | HCID 595156 | — |
Reaction Steps
An aliquot of the so obtained (2RS)-2-(4-isobutylphenyl)-propanoyl chloride (44.8 g; 0.199 moles) is dissolved in acetone (200 ml); this solution is added dropwise to a suspension of triphenyl phosphine (112 g; 0.427 moles) and bistriphenyl phosphine cupper boron hydride (128 g; 0.212 moles) in acetone (600 ml) kept under stirring at 20° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US04840936 |
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| Source dataset | uspto-grants-1989_06 |
|---|
| ORD ID | ord-c8961b7cc9444f9cbfe877e15011c9ed |
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| Source note | uspto-grants-1989_06 |
|---|
