Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Acetonitrile → Methyl 1-benzyl-3-phenylpyrrolidine-3-carboxylate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Acetonitrile | HCID 6342 | — |
| 반응물 | Methyl atropate | HCID 193334 | — |
| 반응물 | N-Benzyl-N-(trimethylsilylmethyl)aminoacetonitrile | HCID 560960 | — |
| 촉매 | Caswell No. 736 | HCID 62656 | — |
| 용매 | Chloroform | HCID 6212 | — |
| 생성물 | Methyl 1-benzyl-3-phenylpyrrolidine-3-carboxylate | HCID 14476557 | 41.1% |
반응 단계
A suspension of 53.4 g (0.23 mol) of N-benzyl-N-(cyanomethyl)-N-[(trimethylsilyl)methyl]amine (J. Org. Chem., 50, 4006 (1985)), 41.2 g (0.25 mol) of methyl atropate, 32.2 g (0.25 mol) of silver fluoride and 1 l of acetonitrile was stirred overnight at room temperature in the dark. The mixture was diluted with chloroform and filtered through celite. Concentration of the filtrate gave an oil which was chromatographed on silica gel, eluting with an 80:20 chloroform:ethyl acetate mixture, to give 27.9 g of methyl 3-phenyl-1-(phenylmethyl)-3-pyrrolidinecarboxylate.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04840956 |
| 출처 데이터셋 | uspto-grants-1989_06 |
| ORD ID | ord-b9d5aaa11717453d8dc721d0fc89bbd0 |
| 출처 메모 | uspto-grants-1989_06 |