Formaldehyde → HCID 13392724, compound

Participants

Reaction Steps

In 50 ml of methanol was dissolved 3.8 g of 6-cetyloxy-2-isopropyl-2H-pyran-3(6H)-one with stirring. Into the solution were added 1.02 g of piperidine and 1.05 g of 37% formalin solution, and the mixture was stirred at 55 ° to 60° C. for 7 hours. After the removal of methanol, the residue was separated by a silica gel column (developer: benzene/ethyl acetate=5/1) to give 4.62 g of 6-cetyloxy-4-piperidinomethyl-2-isopropyl-2H-pyran-3(6H)-one [compound 3] in a yellowish brown viscous oily form.

Provenance & Evidence