Potassium Carbonate → Ethyl 7-chloro-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylate

HRID 1904920노트

반응식

HRID 1904920 반응식
Cl[C:2]1[C:7]([C:8]([C:10](=[CH:16][NH:17][CH:18]2[CH2:20][CH2:19]2)[C:11]([O:13][CH2:14][CH3:15])=[O:12])=[O:9])=[CH:6][C:5]([F:21])=[C:4]([Cl:22])[N:3]=1.C(=O)([O-])[O-].[K+].[K+]>CN(C)C=O>[Cl:22][C:4]1[N:3]=[C:2]2[C:7]([C:8](=[O:9])[C:10]([C:11]([O:13][CH2:14][CH3:15])=[O:12])=[CH:16][N:17]2[CH:18]2[CH2:20][CH2:19]2)=[CH:6][C:5]=1[F:21]

참가 물질

4

반응물 2

HCID 11430Potassium CarbonateHCID 178471870HCID 178471870, 화합물

생성물 1

HCID 11722954Ethyl 7-chloro-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylate수율 94%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

12.5 g (36 mmol) of ethyl 2-(2,6-dichloro-5-fluoro-pyridine-3-carbonyl)-3-cyclopropylamino-acrylate are heated at 100° C. in 75 ml of dimethylformamide with 6.5 g of potassium carbonate for 1 hour. The reaction mixture is poured onto ice-water and the product which has precipitated is filtered off with suction, washed with water and methanol and dried. 10.5 g (94% of theory) of ethyl 7-chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylate of melting point 176°-180° C. are obtained.

후처리

  1. additionThe reaction mixture is poured onto ice-water
  2. customthe product which has precipitated
  3. filtrationis filtered off with suction
  4. washwashed with water and methanol
  5. customdried

출처 및 근거

ORD 기록
ord-8d46baa77e694a49bdcbcac89335b47c
출처 데이터셋
uspto-grants-1989_06
특허 번호
US04840954

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