Acetic Acid → HCID 20036333, compound

HRID 1904931Notes

Reaction equation

HRID 1904931 reaction equation
[C:1]([OH:4])(=[O:3])C.[CH:5]([OH:7])=O.C(OC(=O)C)(=O)C.[CH3:15][N:16]1[CH2:21][CH2:20][CH:19]([CH:22]2[C:28]3[CH:29]=[CH:30][CH:31]=[C:32]4[CH2:33][CH2:34][N:26]([C:27]=34)[C:25]3[CH:35]=[CH:36][CH:37]=[CH:38][C:24]=3[NH:23]2)[CH2:18][CH2:17]1>CO>[CH:1]([OH:4])=[O:3].[CH:5]([N:23]1[CH:22]([CH:19]2[CH2:20][CH2:21][N:16]([CH3:15])[CH2:17][CH2:18]2)[C:28]2[CH:29]=[CH:30][CH:31]=[C:32]3[CH2:33][CH2:34][N:26]([C:27]=23)[C:25]2[CH:35]=[CH:36][CH:37]=[CH:38][C:24]1=2)=[O:7]

Participants

6

Reactant 4

HCID 176Acetic AcidHCID 284Formic AcidHCID 7918Acetic AnhydrideHCID 14459738HCID 14459738, compound

Product 1

HCID 20036333HCID 20036333, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A solution of acetic acid (14.1 ml) and formic acid (14.8 ml) was prepared at -10° C. (methanol-ice) over a period of 1.5 hours. This solution, the mixed formic/acetic anhydride reagent, was added to 6-(1-methylpiperidin-4-yl)-1,2,6,7-tetrahydrobenzo[b]pyrrolo[3,2,1-jk][1,4]benzodiazepine (16 gm) at room temperature in one portion. The mixture was stirred for 30 minutes. The resulting solution was treated with methanol (30 ml) and concentrated to an oil.

Workup

  1. concentrationconcentrated to an oil

Sources & evidence

ORD record
ord-dea03fe3c6b0448a85c54ba12d7407c7
Source dataset
uspto-grants-1989_06
Patent number
US04840947

Reaction notes

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