Benzyl Bromide → 3-ethoxycarbonyl-9-benzylthio-4H-pyrido[1,2-a]pyrimidin-4-one

HRID 1904936노트

반응식

HRID 1904936 반응식
[CH2:1]([O:3][C:4]([C:6]1[C:11](=[O:12])[N:10]2[CH:13]=[CH:14][CH:15]=[C:16]([SH:17])[C:9]2=[N:8][CH:7]=1)=[O:5])[CH3:2].[CH2:18](Br)[C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1.C([O-])([O-])=O.[K+].[K+]>CN(C=O)C.O>[CH2:1]([O:3][C:4]([C:6]1[C:11](=[O:12])[N:10]2[CH:13]=[CH:14][CH:15]=[C:16]([S:17][CH2:18][C:19]3[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=3)[C:9]2=[N:8][CH:7]=1)=[O:5])[CH3:2]

참가 물질

6

반응물 3

HCID 7498Benzyl BromideHCID 11430Potassium CarbonateHCID 143064713-ethoxycarbonyl-9-mercapto-4H-pyrido[1,2-a]pyrimidin-4-one

생성물 1

HCID 143064153-ethoxycarbonyl-9-benzylthio-4H-pyrido[1,2-a]pyrimidin-4-one수율 95.3%

시약·촉매·용매 2

HCID 962Water용매HCID 6228Dimethylformamide용매

실험 절차

To a suspension of 0.3 g of 3-ethoxycarbonyl-9-mercapto-4H-pyrido[1,2-a]pyrimidin-4-one II-1 in 4 ml of anhydrous DMF are added 0.3 g of benzyl bromide VI-1 and 0.5 g of K2CO3, and the resultant mixture is stirred at room temperature for 5 hours. The reaction mixture is diluted with water. The crystal precipitated is filtered and dissolved in CHCl3. The chloroform solution is dried over Na2SO4 and evaporated to give 0.389 g of the titled compound Ic-21.

후처리

  1. customThe crystal precipitated
  2. filtrationis filtered
  3. dissolutiondissolved in CHCl3
  4. dry with materialThe chloroform solution is dried over Na2SO4
  5. customevaporated

출처 및 근거

ORD 기록
ord-e54ac2431a0d4c8bb049d55d4205e313
출처 데이터셋
uspto-grants-1989_06
특허 번호
US04840953

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