反应详情

To a mixture of 0.8 g of 3-ethoxycarbonyl-9-mercapto-4H-pyrido[1,2-a]pyrimidin-4-one II-1, 0.5 g of powdery potassium carbonate and 25 ml of acetone is added 0.7 g of 4-n-butoxybenzoyl chloride with stirring, and the resultant mixture is stirred at room temperature for 2 hours. The resultant precipitate is filtered and distributed in water-chloroform. The chloroform layer is washed with saturated brine, dried over sodium sulfate and concentrated. The residue (1.1 g) is chromatographed on a column of silica gel, eluting with ethyl acetate. Concentration of the eluate affords 0.7 g of the titled compound.

1. filtrationThe resultant precipitate is filtered
2. washThe chloroform layer is washed with saturated brine
3. dry with materialdried over sodium sulfate
4. concentrationconcentrated
5. customThe residue (1.1 g) is chromatographed on a column of silica gel
6. washeluting with ethyl acetate