Phenylacetyl chloride → HCID 14306427, compound

Participants

Reaction Steps

To a solution of 0.129 g of 9-(dimethylcarbamoyl)thio-3ethoxycarbonyl-4H-pyrido[1,2-a]pyrimidin-4-one Ib-85 in 5 ml of 1,2-dichloroethane are added 65 μl of phenylacetyl chloride and 0.13 g of zinc iodide, and the resultant mixture is refluxed in a nitrogen stream for 45 minutes. After cooling, the reaction mixture is shaken with N-hydrochloric acid and the organic layer is washed with saturated brine in order, dried and concentrated in vacuo. The residue is chromatographed on a column of silica gel, eluting with ethyl acetate, whereby 0.118 g of the titled compound Ie-84 is obtained.

Provenance & Evidence