3-(Benzyloxy)-1,2-dimethylpyridin-4(1H)-one → Deferiprone

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Reaction Steps

1,2-Dimethyl-3-benzyloxypyrid-4-one (2 g) is added to concentrated hydrobromic acid (10 ml) and heated in a steam bath for 30 minutes. The resulting mixture is then recrystallised from water to yield 1,2-dimethyl-3-hydroxypyrid-4-one (1 g), m.p. 230° C. (with decomposition); νmax (nujol) 1620, 3150 cm-1 ; δ(d6DMSO) 2.3(s, 3H), 3.8(s, 3H), 6.9(d, 1H), 7.8(d, 1H); M+ 139.

Provenance & Evidence