Ammonium Hydroxide → HCID 14476494, compound

Participants

Reaction Steps

A solution of 5,6-methylenedioxy-1-benzenesulfonylindole-2-sulfonyl chloride (3.66 gm, 9.15 mmol) in acetone (35 ml) was added dropwise to a solution of concentrated ammonium hydorxide (5 ml) in acetone (20 ml) which was cooled in an ice bath. After 1 hour the reaction was warmed to room temperature and the solvent was evaporated. The residue was suspended in cold water and crystalline solid was collected by filtration. This solid was dissolved in ethyl acetate, dried (anhydrous Na2SO4), evaporated, and the residue was triturated with diethyl ether to give crystalline product (1.75 gm), mp 229°-232° C.

Provenance & Evidence