Dibromomethane → 1,3-Benzodioxole-4-carboxaldehyde

Participants

Reaction Steps

A mixture containing 2,3-dihydroxybenzaldehyde, (50 g) dibromomethane (188 g), potassium carbonate (150 g) and copper (II) oxide (1.4 g) in dimethylformamide (2 L) was heated at reflux for 4 hours. The reaction mixture was cooled, filtered and evaporated. The residue was dissolved in toluene and the organic layer was washed with staurated sodium bicarbonate and brine. The layer was then dried, filtered and evaporated to yield 46.5 g of 2,3-methylenedioxybenzaldehyde mp 32°-33° C.

Provenance & Evidence