Sodium hydride → HCID 14517065, compound

Participants

Reaction Steps

Under a nitrogen atmosphere, 135 mg of sodium hydride (60% oil dispersion) was added to 20 ml of dry THF. A solution of 0.30 g or 2-(4-chlorophenyl)3,3,3-trifluoropropanol and 0.34 g of 3-phenoxybenzyl bromide in 20 ml of dry THF was then added with ice-cooling, and the reaction solution was stirred with ice-cooling for 1 hour and at room temperature for 12 hours. Thereafter, the reaction mixture was poured into dilute HCl-ice water and extracted twice with diethyl ether. The ether layers were combined, washed with saturated sodium chloride solution and dried over anhydrous magnesium sulfate. The solvent was removed under a reduced pressure, and the residue was subjected to column chromatography on silica gel [eluted with n-hexane/toluene (2:1) mixture] to obtain 250 mg of the desired compound.

Provenance & Evidence