Sodium Hydroxide → HCID 14517065, compound

Participants

Reaction Steps

Under a nitrogen atmosphere, a solution of 12.58 g of 3-phenoxybenzyl bromide and 10.74 g of 2-(4-chlorophenyl)3,3,3-trifluoropropanol in 30 ml of toluene was slowly added to the mixture of 1.00 g of benzyltriethylammonium chloride, 12.76 g of 45% aqueous sodium hydroxide solution and 15 ml of toluene with ice-cooling. The reaction solution was stirred at room temperature for 14 hours. Thereafter, the reaction solution was poured into dilute hydrochloric acid-ice water and extracted with toluene. The toluene layer was washed with water and dried over anhydrous magnesium sulfate. The solvent was removed under a reduced pressure, and the residue was subjected to column chromatography on silica gel [eluted with n-hexane/toluene (2:1) mixture] to obtain 16.06 g of the desired compound.

Provenance & Evidence