Potassium Hydroxide → HCID 14580833, compound

Participants

Reaction Steps

Into a solution of 4.8 g of potassium hydroxide in 20 ml of ethanol and 5 ml of water, 8.0 g or ethyl 3-(4-methylphenyl)-2,3-epoxy-4,4,4-trifluorobutyrate was added with ice-cooling. The reaction solution was stirred at room temperature for 3 hours. Thereafter, the reaction solution was poured into ice water. The resulting solution was washed with diethyl ether and adjusted to pH 3 with 10% HCl and extracted twice with diethyl ether. The ether layers were combined and washed with saturated sodium chloride solution and dried over anhydrous magnesium sulfate. The solvent was removed under a reduced pressure and the residue was subjected to distillation under a reduced pressure by heating in an oil bath (140°-160° C.) to obtain 3.0 g of the desired aldehyde (b.p. 110°-120° C./110-120 mmHg).

Provenance & Evidence