P-Cresol → 4-Methylphenyl acetate

Participants

Reaction Steps

Into a reaction flask equipped with a stirrer and thermometer was charged 216 grams (2.0 moles) of p-cresol, 225 grams (2.2 moles) of acetic anhydride and 500 milliliters of pyridine and the resulting reaction mixture was then heated to a temperature of 50° C.-55° C. After completion of the reaction, work-up and distillation at reduced pressure, 272 grams of p-methylphenyl acetate was obtained (91 percent of theoretical). The nuclear magnetic resonance (NMR) spectrum was consistent with the chemical structure.

Provenance & Evidence