Sodium Azide → HCID 451826, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 5-ethyl-5'-O-tosyl-2'-deoxyuridine (550 mg, 1.34 mmole) and sodium azide (480 mg, 7.4 mmole) or lithium azide (400 mg) in dry dimethylformamide (10 ml) is heated at 85° C. for 2 hr. Tlc indicates all the starting material has reacted. The solvent is evaporated in vacuo to dryness, and the remaining material is triturated with ice-cold water, filtered to collect the product, and dried over P2O5 to give a white solid (340 mg, 90%), m.p. 174°-177° C.

Provenance & Evidence