HRID1905

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID10376046

3-[(tert-Butoxycarbonyl)amino]-3-methylbutanoic acid

C10H19NO4

结构：CC[C@@H](N)C(=O)N(Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1)c1ccccc1.Cl

HCID178418279

未命名化合物

PRODUCTS

生成物

结构：CC[C@@H](NC(=O)CC(C)(C)NC(=O)OC(C)(C)C)C(=O)N(Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1)c1ccccc1

HCID178418383

未命名化合物

PROCEDURE

实验过程

Prepared as in Example 1, Step N from (R)-2-amino-N-phenyl-N-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]butanamide, hydrochloride and 3-t-butoxycarbonylamino-3-methylbutanoic acid, N-hydroxysuccinimide ester.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-a78a3036fc884a618177322321075319
来源数据集: uspto-grants-1998_03
DOI: 10.6084/m9.figshare.5104873.v1
专利: US05726319
来源说明: uspto-grants-1998_03

反应 SMILES

Cl.[NH2:2][C@H:3]([CH2:31][CH3:32])[C:4]([N:6]([C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=1)[CH2:7][C:8]1[CH:13]=[CH:12][C:11]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=2[C:20]2[NH:24][N:23]=[N:22][N:21]=2)=[CH:10][CH:9]=1)=[O:5].[C:33]([O:37][C:38]([NH:40][C:41]([CH3:47])([CH3:46])[CH2:42][C:43](O)=[O:44])=[O:39])([CH3:36])([CH3:35])[CH3:34]>>[C:33]([O:37][C:38]([NH:40][C:41]([CH3:47])([CH3:46])[CH2:42][C:43]([NH:2][C@H:3]([CH2:31][CH3:32])[C:4]([N:6]([C:25]1[CH:26]=[CH:27][CH:28]=[CH:29][CH:30]=1)[CH2:7][C:8]1[CH:9]=[CH:10][C:11]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=2[C:20]2[NH:24][N:23]=[N:22][N:21]=2)=[CH:12][CH:13]=1)=[O:5])=[O:44])=[O:39])([CH3:36])([CH3:35])[CH3:34]