Hydrochloric Acid → HCID 70396257, compound

Participants

Reaction Steps

6β-Bromo-1,2β-methylenandrost-4-ene-3,17-dione (200 mg) in acetic acid (15 ml) at 15°-20° is treated with a steady stream of dry hydrogen chloride for 1 hour and then kept an additional hour at room temperature. Then water is added and the product isolated with ether. The combined ether extracts are washed with saturated salt solution, 5% sodium carbonate solution, water; dried and evaporated. Column chromatography of residue over silica gel using benzene/ethyl ether as eluant affords pure 6α-bromo-1,2β-methylenandrost-4-ene-3,17-dione (150 mg, 75%).

Provenance & Evidence