1-Morpholino-3-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenoxy)propan-2-ol → 1-(4-{6-Amino-5-[1-(2,6-dichloro-3-fluoro-phenyl)-ethoxy]-pyridin-3-yl}-phenoxy)-3-morpholin-4-yl-propan-2-ol

HRID 190508Notes

Reaction equation

HRID 190508 reaction equation
[Br:1][c:2]1[cH:3][c:4]([O:9][CH:10]([CH3:11])[c:12]2[c:13]([Cl:20])[c:14]([F:19])[cH:15][cH:16][c:17]2[Cl:18])[c:5]([NH2:8])[n:6][cH:7]1.[O:21]1[CH2:22][CH2:23][N:24]([CH2:27][CH:28]([CH2:29][O:30][c:31]2[cH:32][cH:33][c:34]([B:37]3[O:38][C:39]([CH3:40])([CH3:41])[C:42]([CH3:43])([CH3:44])[O:45]3)[cH:35][cH:36]2)[OH:46])[CH2:25][CH2:26]1>>[c:2]1(-[c:34]2[cH:33][cH:32][c:31]([O:30][CH2:29][CH:28]([CH2:27][N:24]3[CH2:23][CH2:22][O:21][CH2:26][CH2:25]3)[OH:46])[cH:36][cH:35]2)[cH:3][c:4]([O:9][CH:10]([CH3:11])[c:12]2[c:13]([Cl:20])[c:14]([F:19])[cH:15][cH:16][c:17]2[Cl:18])[c:5]([NH2:8])[n:6][cH:7]1

Participants

3

Reactant 2

HCID 211113791-Morpholino-3-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenoxy)propan-2-olHCID 211114785-Bromo-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)pyridin-2-amine

Product 1

HCID 211107371-(4-{6-Amino-5-[1-(2,6-dichloro-3-fluoro-phenyl)-ethoxy]-pyridin-3-yl}-phenoxy)-3-morpholin-4-yl-propan-2-ol

Sources & evidence

ORD record
ord-69259b3149c2451cbe8de0715ce98294
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Reaction notes

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