p-Toluenesulfonic acid monohydrate → HCID 13821616, compound

Participants

Reaction Steps

A solution of 2.89 g (10.0 mmol) of ethyl 3-oxo-5-phthalimidopentanoate in 14 ml of allyl alcohol was heated at 80° C. in the presence of catalytic amounts of p-toluenesulphonic acid hydrate for 3 days. The solvent was then evaporated in vacuo and the residue was purified by chromatography on 170 g of silica gel (toluene:ethyl acetate 4:1). The title compound was obtained as colorless crystals, melting point: 53°-55° C., Rf: 0.40 (toluene:ethyl acetate 4:1).

Provenance & Evidence