反应详情

A solution of 4.00 g of 2-(1-naphthylmethylene)-3-(phenethylcarbamoyl)propionic acid in 120 ml of acetic acid was hydrogenated over 2.0 g of a 10% palladium-charcoal under a hydrogen atmosphere at room temperature. After filtration of the catalyst, the filtrate was evaporated under reduced pressure, and hexane was added to the residue. The precipitated crystals were collected by filtration to obtain 3.40 g of (±)-2-(1-naphthylmethyl)-3-(phenethylcarbamoyl)-propionic acid as colorless crystals.

1. filtrationAfter filtration of the catalyst
2. customthe filtrate was evaporated under reduced pressure, and hexane
3. additionwas added to the residue
4. filtrationThe precipitated crystals were collected by filtration