Methyl iodide → HCID 9926647, compound

Participants

Reaction Conditions

Reaction Steps

1 g of 2,2'-O-dimethyladenosine (Compound 5) was dissolved in 5 ml of dimethylformamide, and 2 ml of methyl iodide was added thereto and the solution was stirred for 30 to 40 minutes. After the solvent was distilled off, 5 ml of 0.5N sodium hydroxide was added and the solution was heated for 75 minutes at 100° C. The solution was neutralized and desalted by hydrophobic column chromatography, and then recrystallized from methanol to give 2,N6,2'-O-trimethyladenosine (Compound 21).

Provenance & Evidence