Sodium Hydroxide → HCID 15485096, compound

Participants

Reaction Conditions

Reaction Steps

3 g of 2-amino-2'-O-methyladenosine, the Compound 30 in Example 15, was dissolved in 35 ml of 42% fluoboric acid. 1.3 g/10 ml aqueous solution of sodium nitrite was added to the solution with stirring at -5° C. to -10° C. and stirred for one hour. The reaction mixture was cooled to -20° C. and neutralized by 50% sodium hydroxide aqueous solution. The solution was desalted by hydrophobic column chromatography and crystallized from methanol to give 697 mg of 2-fluoro-2'-O-methyladenosine (Compound 29).

Provenance & Evidence