Hydrogen Peroxide → HCID 14098727, compound

Participants

Reaction Steps

To a mixture of 4.7 g of 2-(4-chlorophenyl)-2,3,4,4a-tetrahydro-5H-(1)benzothiopyrano[4,3-c]pyridazin-3-one 6-oxide in 150 ml of acetic acid is added 55 ml of 35% hydrogen peroxide dropwise with stirring at room temperature. After the completion of addition, the mixture is stirred at 40°-50° C. on a water bath for 4 hours and poured into an excess amount of water. The precipitated crystals are collected by filtration and recrystallized from 50% aqueous solution of acetic acid to give 2.9 g of 2-(4-chlorophenyl)-2,3,4,4a-tetrahydro-5H-(1)benzothiopyrano[4,3-c]pyridazin-3-one 6,6-dioxide, melting at 168°-170° C., as a colorless powder.

Provenance & Evidence