8-Quinolinol, 5-benzyl- → HCID 15631321, compound

Participants

Reaction Steps

To a solution of 702.8 mg (2.99 mmol) of 5-(phenylmethyl)-8-quinolinol in 40 ml of methanol and 8 ml of ethyl acetate under nitrogen was added 200 mg of platinum oxide and the mixture was hydrogenated at 40 PSI for four hours. Filtration through a 0.4 μm polyester membrane filter followed by evaporation yielded 733.8 mg of a dark tan solid. Recrystallization from dichloromethane:hexane and then flash chromatography on 50 g of silica eluted with 3:7 ethyl acetate:petroleum ether provided 534.5 mg: melting point 135°-136° C.

Provenance & Evidence