Hydrochloric Acid → HCID 15631322, compound

Participants

Reaction Steps

A solution of 199.8 mg (0.83 mmol) of 1,2,3,4-tetrahydro-5-(phenylmethyl)-8-quinolinol in 2 ml of dichloromethane was treated with 1 ml of hydrogen chloride-saturated dichloromethane. The addition of 15 ml of hexane resulted in the precipitation of a yellow solid. Microanalysis indicated that this material contained approximately 10% of the free base of the starting material. This mixture was taken up in 1 ml of methanol and treated with 0.5 ml of hydrogen chloride-saturated methanol, then 2 ml of dichloromethane and 10 ml of hexane. Evaporation gave a pale yellow, waxy solid, which was triturated with 5 ml of dichloromethane and 5 ml of hexane. Filtration provided 147.6 mg of the title compound as a pale yellow solid:melting point 219°-221° C. (decomposition 190°-219° C.).

Provenance & Evidence