反应详情

1.0 Gram (0.0043 mole) of 1,3-dimethyl-5-phenoxypyrazole-4-carbaldehyde oxime was dissolved in 20 ml of dimethyl sulfoxide, and after adding 0.3 g (0.0053 mole) of powdery potassium hydroxide, the resulting solution was stirred. To this solution was added 0.92 g (0.0043 mole) of S-ethyl 4-cloromethylbenzothiate, and reaction was carried out at room temperature for 3 hours. After completion of the reaction, 200 ml of water was added to the reaction solution which was then extracted with ethyl acetate. The ethyl acetate extract was washed with water and dried, and ethyl acetate was removed by evaporation to obtain an oily product. This oily product was column-chromatographed on silica gel to obtain 1.4 g of the desired compound.

1. additionTo this solution was added
2. additionwas added to the reaction solution which
3. extractionwas then extracted with ethyl acetate
4. extractionThe ethyl acetate extract
5. washwas washed with water
6. customdried
7. customethyl acetate was removed by evaporation
8. customto obtain an oily product
9. customThis oily product was column-chromatographed on silica gel