反应详情

1.0 Gram (0.0043 mole) of 1,3-dimethyl-5-phenoxypyrazole-4-carbaldehyde oxime and 0.3 g (0.0054 mole) of powdery potassium hydroxide were added to 20 ml of dimethyl sulfoxide, and the resulting mixture was stirred for 30 minutes. To this solution was added 0.8 g (0.0043 mole) of 2-chloroethyl benzoate, and reaction was carried out at from 40° to 50° C. for 3 hours. After completion of the reaction, water was added to the reaction solution which was then extracted with ethyl acetate. The ethyl acetate was washed with water and dried, and ethyl acetate was removed by evaporation to obtain an oily product. This oily product was column-chromatographed on silica gel to obtain 1.3 g of the desired compound.

1. additionTo this solution was added
2. waitwas carried out at from 40° to 50° C. for 3 hours
3. additionwas added to the reaction solution which
4. extractionwas then extracted with ethyl acetate
5. washThe ethyl acetate was washed with water
6. customdried
7. customethyl acetate was removed by evaporation
8. customto obtain an oily product
9. customThis oily product was column-chromatographed on silica gel