6-[4-(2-methyl-2-nitropropylamino)phenyl]-5-methyl-4,5-dihydro-3(2H)-pyridazinone → 6-[4-(2-amino-2-methylpropyl amino)phenyl]-5-methyl-4,5-dihydro-3(2H)-pyridazinone

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Reaction Steps

A mixture of 6-[4-(2-methyl-2-nitropropylamino)phenyl]-5-methyl-4,5-dihydro-3(2H)-pyridazinone (412.6 g), Raney nickel (100 ml) and dimethylformamide (1.5 liters) was hydrogenated under atmospheric pressure. After the absorption of hydrogen ceased, the catalyst was removed by filtration. The filtrate was concentrated under reduced pressure. The residue was recrystallized from methanol to give 6-[4-(2-amino-2-methylpropylamino)phenyl]-5-methyl-4,5-dihydro-3(2H)-pyridazinone (340.39 g).

Provenance & Evidence