HCID 9999750, compound → HCID 10004971, compound

HRID 1905424Notes

Reaction equation

HRID 1905424 reaction equation
[F:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][C:11]=1[N:12]1[CH2:17][CH2:16][NH:15][CH2:14][CH2:13]1)[N:8]1[CH:18]([C:20]3[CH:25]=[CH:24][C:23]([F:26])=[CH:22][CH:21]=3)[S:19][C:7]1=[C:6]([C:27]([O:29][CH2:30][CH3:31])=[O:28])[C:5]2=[O:32].F[C:34]1C=C2C(=CC=1N1CCNC(C)C1)N1C(C3C=CC(F)=CC=3)SC1=C(C(OCC)=O)C2=O.FC1C=C2C(=CC=1N1CCN(C)C(C)C1)N1C(C3C=CC(F)=CC=3)SC1=C(C(OCC)=O)C2=O.ClC1C=CC(C2N3C4C(C(=O)C(C(OCC)=O)=C3S2)=CC(F)=C(N2CCN(C)CC2)C=4)=CC=1.ClC1C=CC(C2N3C4C(C(=O)C(C(OCC)=O)=C3S2)=CC(F)=C(N2CCNCC2)C=4)=CC=1.ClC1C=CC(C2N3C4C(C(=O)C(C(OCC)=O)=C3S2)=CC(F)=C(N2CCNC(C)C2)C=4)=CC=1.ClC1C=CC(C2N3C4C(C(=O)C(C(OCC)=O)=C3S2)=CC(F)=C(N2CCN(C)C(C)C2)C=4)=CC=1.FC1C=C2C(=C(OC)C=1N1CCNCC1)N1C(C)SC1=C(C(O)=O)C2=O>>[F:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][C:11]=1[N:12]1[CH2:13][CH2:14][N:15]([CH3:34])[CH2:16][CH2:17]1)[N:8]1[CH:18]([C:20]3[CH:21]=[CH:22][C:23]([F:26])=[CH:24][CH:25]=3)[S:19][C:7]1=[C:6]([C:27]([O:29][CH2:30][CH3:31])=[O:28])[C:5]2=[O:32]

Participants

9

Reactant 8

HCID 9999750HCID 9999750, compoundHCID 14421148HCID 14421148, compoundHCID 14421164HCID 14421164, compoundHCID 20035480HCID 20035480, compoundHCID 20035481HCID 20035481, compoundHCID 20035483HCID 20035483, compoundHCID 20035489HCID 20035489, compoundHCID 20035494HCID 20035494, compound

Product 1

HCID 10004971HCID 10004971, compound

Procedure

ethyl 6-fluoro-1-(4-fluorophenyl)-4-oxo-7-(1-piperazinyl)-4H-(1,3)thiazeto(3,2-a)quinoline-3-carboxylate; ethyl 6-fluoro-1-(4-fluorophenyl)-7-(3-methyl-1-piperazinyl)-4-oxo-4H-(1,3)thiazeto(3,2-a)quinoline-3-carboxylate; ethyl 6-fluoro-1-(4-fluorophenyl)-7-(3,4-dimethyl-1-piperazinyl)-4-oxo-4H-(1,3)thiazeto(3,2-a)quinoline-3-carboxylate; ethyl 1-(4-chlorophenyl)-6-fluoro-7-(4-methyl-1-piperazinyl)-4-oxo-4H-(1,3)thiazeto(3,2-a)quinoline-3-carboxylate; ethyl 1-(4-chlorophenyl)-6-fluoro-4-oxo-7-(1-piperazinyl)-4H-(1,3)thiazeto(3,2-a)quinoline-3-carboxylate; ethyl 1-(4-chlorophenyl)-6-fluoro-7-(3-methyl-1-piperazinyl)-4-oxo-4H-(1,3)thiazeto(3,2-a)quinoline-3-carboxylate; ethyl 1-(4-chlorophenyl)-6-fluoro-7-(3,4-dimethyl-1-piperazinyl)-4-oxo-4H-(1,3)thiazeto(3,2-a)quinoline-3-carboxylate; and 6-fluoro-8-methoxy-1-methyl-4-oxo-7 (1piperazinyl)-4H-(1,3)thiazeto(3,2-a)quinoline-3-carboxylic acid (ethyl ester, m.p. 190° C. (decompn.)).

Sources & evidence

ORD record
ord-a33cc4aa491d4dfda244871f606df9e6
Source dataset
uspto-grants-1989_06
Patent number
US04843070

Reaction notes

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