2,6-Difluorobenzoyl isocyanate → 100279-32-1

HRID 1905446Notes

Reaction equation

HRID 1905446 reaction equation
[F:1][C:2]1[CH:12]=[CH:11][CH:10]=[C:9]([F:13])[C:3]=1[C:4]([N:6]=[C:7]=[O:8])=[O:5].[F:14][C:15]1[CH:21]=[C:20]([S:22][C:23]([F:28])([F:27])[CH:24]([F:26])[Cl:25])[CH:19]=[CH:18][C:16]=1[NH2:17]>C1(C)C=CC=CC=1>[F:1][C:2]1[CH:12]=[CH:11][CH:10]=[C:9]([F:13])[C:3]=1[C:4]([NH:6][C:7]([NH:17][C:16]1[CH:18]=[CH:19][C:20]([S:22][C:23]([F:28])([F:27])[CH:24]([F:26])[Cl:25])=[CH:21][C:15]=1[F:14])=[O:8])=[O:5]

Participants

4

Reactant 2

HCID 27333692,6-Difluorobenzoyl isocyanateHCID 13579022HCID 13579022, compound

Product 1

HCID 180800100279-32-1

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

A 1.8 g quantity of 2,6-difluorobenzoyl isocyanate was added dropwise to a solution of 2.6 g of 2-fluoro-4-(1,1,2-trifluoro-2-chloroethylthio)aniline in 15 ml of toluene at room temperature (20°to 25° C.). After the reaction was allowed to proceed at the same temperature for 1 hour, the crystals which separated out were recovered by filtration and washed with toluene to give 3.6 g of N-(2,6-difluorobenzoyl)-N'-[2-fluoro-4-(1,1,2-trifluoro-2-chloroethylthio)phenyl]urea, m.p. of 172°-173° C.

Workup

  1. customthe crystals which separated out
  2. filtrationwere recovered by filtration
  3. washwashed with toluene

Sources & evidence

ORD record
ord-634d92220cfa4fe98ccba768bcf7d046
Source dataset
uspto-grants-1989_06
Patent number
US04843100

Reaction notes

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