2,6-Difluorobenzoyl isocyanate → HCID 13578966, compound

Participants

Reaction Steps

In 20 ml of toluene was dissolved 20 g of 3-(1,1,2-trifluoro-2-chloroethylsulfonyl)aniline, amd 1.4 g of 2,6-difluorobenzoyl isocyanate was added to the solution, followed by stirring at room temperature (20° to 25° C.) for 2 hours. The reaction mixture was concentrated under reduced pressure, and the crystals which separated out were recovered by filtration, and washed with cyclohexane to give 3.3 g of N-(2,6-difluorobenzoyl)-N'-(3-(1,1,2-trifluoro-2-chloroethylsulfonyl)phenyl]urea (Compound No. 38), m.p. of 192°-194° C.

Provenance & Evidence