Cyanide → 4-Cyanopyridine

Participants

Reaction Steps

It has been reported by Fife et al., Heterocycles 22:1121-4(1984) that 3-methyl-1-methoxypyridinium methylsulfate reacted with cyanide ion to give 3-methyl-2-cyanopyridine and "high percentages" of the 4-cyanopyridine isomer. In Table 1 on page 1122, Fife et al. reported that the 4-cyano compound was gobtained in 69% yield and 3-methyl-2-cyanopyridine was obtained in 24% yield.

Provenance & Evidence