HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethylcarbamoyl Chloride → 3-Methyl-1-dimethylcarbamoyloxypyridinium chloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethylcarbamoyl Chloride | HCID 6598 | — |
| Reactant | 3-Picoline-N-oxide | HCID 13858 | — |
| Product | 3-Methyl-1-dimethylcarbamoyloxypyridinium chloride | HCID 13249983 | — |
Reaction Steps
Also, Fife et al., cited hereabove and Heterocycles 22:93-96(1984), reported the reaction of 3-methylpyridine-1-oxide with dimethyl-carbamoyl chloride to give 3-methyl-1-dimethylcarbamoyloxypyridinium chloride. Reaction of this pyridinium salt with potassium cyanide in water gave 3-methyl-2-cyanopyridine (89%) and the 6-isomer (11%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04843163 |
| Source dataset | uspto-grants-1989_06 |
| ORD ID | ord-0ef46d27beeb4da4ad834a52dd0556e3 |
| Source note | uspto-grants-1989_06 |