Hydrochloric Acid → Ethyl 2-amino-3-cyanothieno[3,2-b]thiophene-5-carboxylate

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Reaction Steps

A mixture of 319 parts of N,N-dimethyl-N'-(3-cyano-5-ethoxycarbonylthieno[3,2-b]thien-2-yl)formamidine, 2,000 parts of ethanol and 210 parts of concentrated hydrochloric acid was heated at the boil for 1 hour. After cooling down, the precipitate was filtered off with suction, washed with methanol and then with water and dried. This gave 210 parts (80% of theory) of ethyl 2-amino-3-cyanothieno[3,2-b]thiophene-5-carboxylate.

Provenance & Evidence