HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Iodide → 3-[5-(4-Cyanophenoxy)pentyl]-5-methylisoxazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Iodide | HCID 4875 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 4-Cyanophenol | HCID 13019 | — |
| Reactant | 3-(5-Bromopentyl)-5-methylisoxazole | HCID 13316978 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | 3-[5-(4-Cyanophenoxy)pentyl]-5-methylisoxazole | HCID 13316965 | 53.6% |
Reaction Steps
A mixture of 5.1 g of 4-cyanophenol, 10 g of 3-(5-bromopentyl)-5-methylisoxazole, 8 g of potassium carbonate, 1 g of potassium iodide and 75 ml of acetonitrile was heated at reflux for 24 hours. The product was isolated and distilled, first at 115°-200° C.(0.1 mm) and then at 160°-190° C.(0.05 mm) to yield a yellow oil which crystallized upon cooling. Recrystallization from hexane-ether afforded 6.2 g of 3-[5-(4-cyanophenoxy)pentyl]-5-methylisoxazole, m.p. 61°-62° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04843087 |
| Source dataset | uspto-grants-1989_06 |
| ORD ID | ord-d917943be852459f896ecdcb633b29f8 |
| Source note | uspto-grants-1989_06 |