HuagongsheHuagongshe Chemistry Print Report · For research reference only
tert-Butyl methyl ether → Anticancer agent 73
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | tert-Butyl methyl ether | HCID 15413 | — |
| Reactant | 3-(Chloromethyl)-5-methyl-1,2-oxazole | HCID 2735763 | — |
| Reactant | 2-(4-methoxyphenyl)-4,5-dimethyloxazole N-oxide hydrochloride | HCID 20064023 | — |
| Catalyst | Zinc | HCID 23994 | — |
| Product | Anticancer agent 73 | HCID 20064063 | 61% |
Reaction Steps
2-(4-Methoxyphenyl)-4-carbethoxy-5-methyloxazole was prepared in 61% yield by zinc dust reduction of the compound of part (a) in accordance with the procedure of Example 89, part (b), and obtained as a crystalline material, m.p. 74°-76° C. (from methyl t-butyl ether).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04843087 |
| Source dataset | uspto-grants-1989_06 |
| ORD ID | ord-b45976e1704e44d9b15c212d4bff921f |
| Source note | uspto-grants-1989_06 |