Thionyl Chloride → HCID 20063967, compound

HRID 1905528Notes

Reaction equation

HRID 1905528 reaction equation
S(Cl)(Cl)=O.O[CH2:6][CH2:7][NH:8][C:9](=[O:30])[C:10]1[CH:15]=[CH:14][C:13]([S:16][S:17][C:18]2[CH:29]=[CH:28][C:21]([C:22]([NH:24][CH2:25][CH2:26][OH:27])=O)=[CH:20][CH:19]=2)=[CH:12][CH:11]=1>C(OC(C)C)(=O)C>[O:30]1[CH2:6][CH2:7][N:8]=[C:9]1[C:10]1[CH:11]=[CH:12][C:13]([S:16][S:17][C:18]2[CH:29]=[CH:28][C:21]([C:22]3[O:27][CH2:26][CH2:25][N:24]=3)=[CH:20][CH:19]=2)=[CH:14][CH:15]=1

Participants

4

Reactant 2

HCID 24386Thionyl ChlorideHCID 20063974HCID 20063974, compound

Product 1

HCID 20063967HCID 20063967, compoundYield 85.3%

Reagents, catalysts & solvents 1

HCID 7915Isopropyl AcetateSolvent

Procedure

Thionyl chloride (20.0 g) was added to a stirred suspension of 13.3 g of N,N'-bis(2-hydroxyethyl)-4,4'-dithiobis[benzamide] in 250 ml of isopropyl acetate. The reaction mixture was allowed to stand for 3 days and the solid product was collected and dried to give 10.3 g of bis[4-(4,5-dihydro-2-oxazolyl)phenyl]disulfide, used directly in the next reaction.

Workup

  1. customthe solid product was collected
  2. customdried

Sources & evidence

ORD record
ord-e7047e67e32b4e95b55239371798afcc
Source dataset
uspto-grants-1989_06
Patent number
US04843087

Reaction notes

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