Dicyclohexylcarbodiimide → HCID 14346840, compound

HRID 1905591Notes

Reaction equation

HRID 1905591 reaction equation
C1(N=C=NC2CCCCC2)CCCCC1.[F:16][CH:17]([F:38])[O:18][C:19]1[CH:20]=[N:21][C:22]([C:28]2[NH:29][C:30](=[O:37])[C:31]([CH:34]([CH3:36])[CH3:35])([CH3:33])[N:32]=2)=[C:23]([CH:27]=1)[C:24](O)=[O:25]>C(Cl)Cl>[F:16][CH:17]([F:38])[O:18][C:19]1[CH:27]=[C:23]2[C:24](=[O:25])[N:29]3[C:30](=[O:37])[C:31]([CH:34]([CH3:36])[CH3:35])([CH3:33])[N:32]=[C:28]3[C:22]2=[N:21][CH:20]=1

Participants

4

Reactant 2

HCID 10868DicyclohexylcarbodiimideHCID 13852376HCID 13852376, compound

Product 1

HCID 14346840HCID 14346840, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent2×

Procedure

Dicyclohexylcarbodiimide (1.07 g, 5 mmol) in 20 mL CH2Cl2 is added to a stirred solution containing 1.54 g (4.7 mmol) 5-(difluoromethoxy)-2-(4-isopropyl-4-methyl-5-oxo-2-imidazolin-2-yl)nicotinic acid in 30 mL CH2Cl2 under nitrogen at room temperature. The mixture is stirred overnight, filtered and concentrated to give the product, 7-(difluoromethoxy)-2-isopropyl-2-methyl-5H-imidazo[1',2':1,2]pyrrolo[3,4-b]pyridine-3(2H), 5-dione.

Workup

  1. filtrationfiltered
  2. concentrationconcentrated

Sources & evidence

ORD record
ord-fe2e8f1f0565481fa812b9ff9bd0286d
Source dataset
uspto-grants-1987_03
Patent number
US04647301

Reaction notes

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