HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Amino-2,3-dimethylbutanamide → HCID 13474746, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Amino-2,3-dimethylbutanamide | HCID 9793773 | — |
| Reactant | HCID 13852386 | HCID 13852386 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 13474746 | HCID 13474746 | — |
Reaction Steps
A solution of 6-difluoromethoxyquinoline-2,3-dicarboxylic acid anhydride (0.037 mol) in 250 mL THF is stirred at 5° C. under nitrogen and a solution containing 2-amino-2,3-dimethylbutyramide (0.037 mol) in 50 mL THF added dropwise. After stirring at room temperature for 17 hours, the solvent is removed in vacuo to give the desired 6-difluoromethoxy-2-[(1-carbamoyl-1,2-dimethylpropyl)-carbamoyl]-3-quinolinecarboxylic acid mp 194°-196° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04647301 |
| Source dataset | uspto-grants-1987_03 |
| ORD ID | ord-65a13a873fd14f1ab77c8f8bb052e482 |
| Source note | uspto-grants-1987_03 |