1,1-Bis(methylthio)-2-nitroethylene → 2-(Nitromethylidene)-1-[(pyridin-4-yl)methyl]hexahydropyrimidine

Participants

Reaction Steps

A mixture of N-(4-pyridylmethyl)trimethylenediamine (16.5 g), 1-nitro-2,2-bis(methylthio)ethylene (16.5 g) and methanol (100 ml) was refluxed for 2 hours with stirring. The generated gas was collected by an alkali trap. The reaction mixture was cooled to room temperature, and the resulting crystals were filtered to give 1-(4-pyridylmethyl)-2-(nitromethylene)tetrahydropyrimidine (16 g) of the following formulas as pale yellow crystals. Concentrating the filtrate further gave 3 g of this compound. mp. 226°-228° C. ##STR14##

Provenance & Evidence