HuagongsheHuagongshe Chemistry Print Report · For research reference only
p-Toluenesulfonic acid monohydrate → p-Toluenesulfonic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | p-Toluenesulfonic acid monohydrate | HCID 521998 | — |
| Reactant | 2-(Nitromethylidene)-1-[(pyridin-4-yl)methyl]hexahydropyrimidine | HCID 70249474 | — |
| Solvent | Acetone | HCID 180 | — |
| Solvent | Chloroform | HCID 6212 | — |
| Product | p-Toluenesulfonic acid | HCID 6101 | 210.4% |
Reaction Steps
Compound No. 1 (0.73 g) obtained in Example 1 was dissolved in a mixed solvent of acetone (10 ml) and chloroform (50 ml), and p-toluenesulfonic acid hydrate (0.63 g) was added. The mixture was vigorously shaken for 2 hours, and then allowed to stand at room temperature for 3 hour. The precipitated crystals were collected by filtration, and fully washed with acetone to give the p-toluenesulfonate (1.2 g) of compound No. 1 of this invention. mp. 170°-176° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04647570 |
| Source dataset | uspto-grants-1987_03 |
| ORD ID | ord-660a043b23034f939d0612f5859939fd |
| Source note | uspto-grants-1987_03 |