HuagongsheHuagongshe Chemistry Print Report · For research reference only
Pyridine → N-(3-Formamido-2-oxoazetidin-3-yl)-2-phenoxyacetamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Pyridine | HCID 1049 | — |
| Reactant | Acetic-formic anhydride | HCID 75269 | — |
| Reactant | N-(3-Amino-2-oxoazetidin-3-yl)-2-phenoxyacetamide | HCID 20193893 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | N-(3-Formamido-2-oxoazetidin-3-yl)-2-phenoxyacetamide | HCID 20162888 | 71.8% |
Reaction Steps
The amine (27) (66 mg) in dry dichloromethane (5 ml) was cooled to 0° and treated with pyridine (49 mg) followed by formic-acetic anhydride (27 mg). The mixture was stirred at 0° for 15 minutes then allowed to warm to room temperature over 15 minutes, and evaporated to dryness. The residue was chromatographed on silica gel to give the product (28) (53 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04647558 |
| Source dataset | uspto-grants-1987_03 |
| ORD ID | ord-1f2a519fad954e04a0cd2989fc84efa0 |
| Source note | uspto-grants-1987_03 |