Sodium periodate → HCID 178515176, compound

HRID 1905677Notes

Reaction equation

HRID 1905677 reaction equation
[C:1]1([N:7]2[C:15](=[O:16])[C:14]3[C:9]([C:10]4[CH2:20][S:19][CH2:18][CH2:17][C:11]=4[NH:12][CH:13]=3)=[N:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.I([O-])(=O)(=O)=[O:22].[Na+]>CO.O>[O:22]=[S:19]1[CH2:18][CH2:17][C:11]2[NH:12][CH:13]=[C:14]3[C:15](=[O:16])[N:7]([C:1]4[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=4)[N:8]=[C:9]3[C:10]=2[CH2:20]1

Participants

5

Reactant 2

HCID 23667635Sodium periodateHCID 178515175HCID 178515175, compound

Product 1

HCID 178515176HCID 178515176, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 962WaterSolvent

Procedure

To a solution of 0.3 g of 2,3,5,6,7,9-hexahydro-2-phenylthiopyrano[4,3-b]pyrazolo[3,4-d]pyridin-3-one in 200 mL of methanol, a solution of 0.8 g of sodium metaperiodate in 25 mL of water is added. The mixture is stirred at room temperature for 48 hours, then evaporated to dryness. The residue is washed with 50 mL of water, filtered, and dried in a vacuum oven at 80° overnight obtaining 2,3,5,6,7,9-hexahydro-8-oxo-2-phenylthiopyrano[4,3-b]pyrazolo[3,4-d]pyridin-3-one, m.p. 218°-220° (dec).

Workup

  1. customevaporated to dryness
  2. washThe residue is washed with 50 mL of water
  3. filtrationfiltered
  4. customdried in a vacuum oven at 80° overnight

Sources & evidence

ORD record
ord-a4b97d6f1c324ec9b9b095a32f943650
Source dataset
uspto-grants-1987_03
Patent number
US04647566

Reaction notes

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